Alpha This is a work in progress and may change. Your feedback is very welcome.
  


Welcome to histo.fyi

histo.fyi is a database of 3D structures of Major Histocompatibility Complex (MHC molecules and their ligands which are available in the Protein Databank. It provides data about these molecules in a standardised interface, using the most up to date nomenclature.
The complex of an antigenic peptide and the MHC molecule (pMHC) is the ligand recognised by T-cell receptors (TCR) as part of the adaptive immune response to pathogens and tumors.
The initial focus of this database/website is on MHC Class I molecules. Over time it will be extended to cover MHC Class II molecules and their ligands and non-classical MHC molecules and homologues.

MHC Class I Structures

Species 18different species
Peptide lengths 16different lengths
Complex types 30combinations
Deposition years 31different years

Latest structures

The 10 most recently released structures added from the Protein Data Bank.

7S7F  

HLA-B*07:02 binding "LPASPAHQL" at 1.88Å resolution

CRYSTAL STRUCTURE OF HLA-B*07:02 IN COMPLEX WITH DOT1L(998-1006) PEPTIDE AND PHOSPHOPEPTIDE
Human Deposited 2021 Nonamer peptide (9aa) Class I alpha Beta 2 microglobulin
7S8F  

HLA-B*07:02 binding "EPRSPSHSM" at 1.80Å resolution

STRUCTURE OF HLA-B*07:02 IN COMPLEX WITH MLL(747-755) PEPTIDE AND BOUND GLYCEROL
Human Deposited 2021 Nonamer peptide (9aa) Class I alpha Beta 2 microglobulin
7S8E  

HLA-B*07:02 binding "EPRSPSHSM" at 1.60Å resolution

STRUCTURE OF HLA-B*07:02 IN COMPLEX WITH MLL(747-755) PHOSPHOPEPTIDE AND BOUND GLYCEROL
Human Deposited 2021 Nonamer peptide (9aa) Class I alpha Beta 2 microglobulin
7RZD  

HLA-B*07:02 binding "EPRSPSHSM" at 1.82Å resolution

CRYSTAL STRUCTURE OF HLA-B*07:02 IN COMPLEX WITH MLL(747-755) PEPTIDE
Human Deposited 2021 Nonamer peptide (9aa) Class I alpha Beta 2 microglobulin
7S7D  

HLA-B*07:02 binding "EPRSPSHSM" at 1.56Å resolution

STRUCTURE OF HLA-B*07:02 IN COMPLEX WITH SYNTHETIC SULFO-MLL PEPTIDE ANALOG
Human Deposited 2021 Nonamer peptide (9aa) Class I alpha Beta 2 microglobulin
7S79  

HLA-B*07:02 binding "EPRXPSHSM" at 1.53Å resolution

STRUCTURE OF HLA-B*07:02 IN COMPLEX WITH SYNTHETIC PHOSPHONO-MLL PEPTIDE ANALOG
Human Deposited 2021 Nonamer peptide (9aa) Class I alpha Beta 2 microglobulin
7RZJ  

HLA-B*07:02 binding "EPRSPSHSM" at 1.80Å resolution

CRYSTAL STRUCTURE OF HLA-B*07:02 IN COMPLEX WITH MLL(747-755) PHOSPHOPEPTIDE
Human Deposited 2021 Nonamer peptide (9aa) Class I alpha Beta 2 microglobulin
7RK7  

HLA-A*02:01 presenting "YMDGTMSQV" to Alpha/Beta T cell receptor at 2.54Å resolution

THE COMPLEX BETWEEN TIL 1383I TCR AND HUMAN CLASS I MHC HLA-A2 WITH THE BOUND TYROSINASE(369-377)(N371D) NONAMERIC PEPTIDE
Human Deposited 2021 Nonamer peptide (9aa) Class I alpha Beta 2 microglobulin T cell receptor alpha T cell receptor beta
7S8A  

HLA-B*07:02 binding "EPRSPSHSM" at 2.10Å resolution

STRUCTURE OF HLA-B*07:02 IN COMPLEX WITH MLL(747-755) PHOSPHOPEPTIDE, CUBIC CRYSTAL FORM
Human Deposited 2021 Nonamer peptide (9aa) Class I alpha Beta 2 microglobulin
7S7E  

HLA-B*07:02 binding "LPASPAHQL" at 2.04Å resolution

CRYSTAL STRUCTURE OF HLA-B*07:02 IN COMPLEX WITH DOT1L(998-1006) PEPTIDE AND PHOSPHOPEPTIDE
Human Deposited 2021 Nonamer peptide (9aa) Class I alpha Beta 2 microglobulin

More structures released in the PDB this year.


Creative Commons Licence
This work is licensed under a Creative Commons Attribution 4.0 International License.